我国葡萄膜炎研究的现状及发展

近年来,我国的葡萄膜炎研究已步入国际先进行列.在临床研究方面,我国学者归纳总结出我国葡萄膜炎的临床谱系及特征,对葡萄膜炎的诊断及防治进行了一系列原创性研究;在基础研究方面,发现了葡萄膜炎发生的一个新通路即IL-23/IL-17,揭示出CD4+CD25high调节性T细胞数量减少和功能降低在Vogt-小柳原田综合征发病中起着重要作用,发现了与葡萄膜炎发病有关的数个基因多态,揭示出机体防御眼内炎症机制(前房相关免疫偏离)形成的分子和细胞学基础.这些研究成果多发表在国际著名的杂志上,表明我国对世界葡萄膜炎研究做出了积极贡献.

Recent advances in uveitis studies in China

Uveitis has become an intensive study area and great achievements have been obtained during recent years. Uveitis study team in China has become one of the most productive uveitis study groups in the world. Ophthalmologists in China have addressed the clinical patterns and characteristics of uveitis in China. Studies by Chinese ophthalmologists, for the first time, revealed that IL-23/IL-17 played an important role in the pathogenesis of uveitis. Decreased frequency and function of CD4 + CD25high T cells were shown to be actively involved in the development of Vogt-Koyanagi-Harada syndrome. A number of immunerelated genes were found to be associated with the susceptibility to or resistance against Behcet's disease or Vogt-Koyanagi-Harada syndrome. Various molecules, such as Tim-3 and IDO protein, and Treg cells including CD4 + CD25 + T, CD4 + PD-1 + T, CD8 + Foxp3 + T and CD8 + CD94 + T were found to be involved in the development of anterior chamber associated immune deviation, an important mechanism against intraocular inflammation. These studies have greatly contributed to the understanding as well as the treatment of this disease.