| 中医药调控IL-1治疗肿瘤机制的研究进展 |
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| 引用本文： | 应杉,荣震,莫春梅,陈亚栋,莫媛,郑伟平,王同彪.中医药调控IL-1治疗肿瘤机制的研究进展[J].中华中医药学刊,2020(3):171-174. |
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| 作者姓名： | 应杉 荣震 莫春梅 陈亚栋 莫媛 郑伟平 王同彪 |
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| 作者单位： | 广西中医药大学;嵊州市中医院;广西中医药大学第一附属医院 |
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| 基金项目： | 国家自然科学基金地区项目(81660774,8176150139);广西壮瑶药制剂提升工程(GZZJ16-04);广西壮族自治区卫生厅中医药科技专项(GZYZ1207);广西中医药大学第一附属医院院级科研项目(2016QN021). |
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| 摘 要： | 炎症已成为影响肿瘤细胞增殖转移的第七大因素,而白细胞介素-1(IL-1)是炎性微环境的重要因子之一。中医药在治疗肿瘤时具有多途径、多靶点的优势,同时炎性微环境致病特点与现代中医学"癌毒"的理论相吻合。查阅近年中医药调控IL-1家族分子治疗肿瘤机制的文献,对其进行梳理,并做出概括及评价,从中医药主要调控IL-1α、IL-1β和IL-18因子治疗肿瘤展开综述,为中医药更系统化治疗肿瘤提供参考。
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| 关 键 词： | 中医药 IL-1 肿瘤 机制 |
Research Progress on Mechanism of TCM Regulating IL-1 in Treating Tumor |
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| YING Shan,RONG Zhen,MO Chunmei,CHEN Yadong,MO Yuan,ZHENG Weiping,WANG Tongbiao.Research Progress on Mechanism of TCM Regulating IL-1 in Treating Tumor[J].Chinese Archives of Traditional Chinese Medicine,2020(3):171-174. |
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| Authors: | YING Shan RONG Zhen MO Chunmei CHEN Yadong MO Yuan ZHENG Weiping WANG Tongbiao |
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| Institution: | (Guangxi University of Traditional Chinese Medicine,Nanning 530200,Guangxi,China;Shengzhou Hosptial of TCM,Shengzhou 312400,Zhejiang,China;The First Affiliated Hospital of Guangxi University of Traditional Chinese medicine,Nanning 530023,Guangxi,China) |
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| Abstract: | Inflammation has become the seventh major factor affecting the proliferation and metastasis of tumor cells, and interleukin-1(IL-1) is one of the important factors in the inflammatory microenvironment. Traditional Chinese medicine has the advantages of multiple approaches and targets in the treatment of tumors. At the same time, the characteristics of inflammatory microenvironment are consistent with the theory of "cancer toxicity" in modern traditional Chinese medicine. This paper reviewed the literature on the mechanism of TCM regulating IL-1 family molecular in treating tumor in recent years, sorted them out and made a summary and evaluation. In this review, the main factors of TCM regulating IL-1α, IL-1β and IL-18 in treating tumors were reviewed. It providedthe reference forsystematic treatment of tumor with traditional Chinese medicine. |
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| Keywords: | TCM IL-1 tumor mechanism |
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