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Significance of progressive liver fibrosis in pediatric liver transplants: A review of current evidence |
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| Authors: | Mathew George Philippe Paci Timucin Taner |
| Affiliation: | Mathew George, Philippe Paci, Timucin Taner, Departments of Surgery, Mayo Clinic, Rochester, MN 55905, United StatesTimucin Taner, Departments of Immunology, Mayo Clinic, Rochester, MN 55905, United States |
| Abstract: | This article reviews the current evidence and knowledge of progressive liver fibrosis after pediatric liver transplantation. This often-silent histologic finding is common in long-term survivors and may lead to allograft dysfunction in advanced stages. Surveillance through protocolized liver allograft biopsy remains the gold standard for diagnosis, and recent evidence suggests that chronic inflammation precedes fibrosis. |
| Keywords: | Allograft fibrosis Pediatric liver transplant Chronic rejection Immunosuppression Portal inflammation Liver allograft |
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| 点击此处可从《World journal of gastroenterology : WJG》浏览原始摘要信息 | |