| 短暂性脑缺血发作患者血浆中TXB2和PGF1α含量检测 |
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| 引用本文： | 徐酝宜,孙伟民. 短暂性脑缺血发作患者血浆中TXB2和PGF1α含量检测[J]. 中国临床神经科学, 1994, 2(2): 91-93 |
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| 作者姓名： | 徐酝宜 孙伟民 |
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| 作者单位： | 上海医科大学神经病学研究所 200040(徐酝宜，万伟祖，秦芝九)，上海医科大学数学教研室 200032(孙伟民)，上海医科大学数学教研室 200032(吕梅珍) |
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| 摘 要： | 本文用放射免疫法测定47例短暂性脑缺血发作(TIA)患者血浆中血栓素B_2(TXB_2)和6酮-前列腺F_(1α)(PGF_(1α))的含量。结果发现TIA患者血浆中TXB_2含量增高,PGF_(1α)降低;头颅CT或MRI示有小灶性梗塞者及TIA发作持续时间长于30min者TXB_2升高和PGF_(1α)降低更显著。治疗3个月后,血浆PGF_(1α)显著增高。TXB_2和PGF_(1α)在体内的失平衡是急性脑血管疾病发病的重要机理之一。
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| 关 键 词： | 短暂性脑缺血发作 血栓素B_2 6酮-前列腺素F~1 |
Determination of Plasma Levels of PGFla and TXB_2 in Patients with Transient Ischemic Attacks |
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| Xu Yu-Nyi,Wan Wei-Zu,Qin Zhi-Jiu,Sun Wei-Ming,Li Mei-Zhen Institute of Neurology. Determination of Plasma Levels of PGFla and TXB_2 in Patients with Transient Ischemic Attacks[J]. Chinese Journal of Clinical Neurosciences, 1994, 2(2): 91-93 |
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| Authors: | Xu Yu-Nyi Wan Wei-Zu Qin Zhi-Jiu Sun Wei-Ming Li Mei-Zhen Institute of Neurology |
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| Affiliation: | Xu Yu-Nyi,Wan Wei-Zu,Qin Zhi-Jiu,Sun Wei-Ming,Li Mei-Zhen Institute of Neurology,Department of Mathematics .Shanghai Medical University |
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| Abstract: | The plasma levels of 6-Kete-Prostaglandin Fla(PGFla)and thromboxane B2(TXB2) in 47 patients with transient ischemic attacks(TIA)were determined by radio-immunoassay. An increase of TXB2 and a decrease of PGFla were found in TIA patients. The higher TXB2 level and lower PGFla level were found in TIA patients with infarction on CT or MRI and in patients with ischemic attacks lasting more than 30 min. But PGFla level had a significant increase after three months treatment. The imbalance between PGFlaand TXB2 is one of the important pathogenicities of acute cerebral vascular diseases. |
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| Keywords: | Transient ischemic attack Thromboxane B2 6-Keto-Prostaglandin |
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