5-Hydroxyindoleacetic acid in cerebrospinal fluid of patients with Parkinson's syndrome treated with L-DOPA |
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| Authors: | B. Johansson B. E. Roos |
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| Affiliation: | (1) Departments of Neurology and Pharmacology, University of Göteborg, Göteborg, Sweden |
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| Abstract: | ![]()
Summary 5-Hydroxytryptamine (5-HT) turnover has been studied in eleven patients with Parkinson's disease before and during L-DOPA administration, using a test based on the fact that probenecid inhibits the active transport of acid monoamine metabolites, such as 5-hydroxyindoleacetic acid (5-HIAA), from cerebrospinal fluid to blood. A significant decrease in 5-HT turnover was observed during L-DOPA treatment, and possible mechanisms for it are discussed. |
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| Keywords: | Parkinsonism 5-hydroxyindoleacetic acid cerebrospinal fluid L-DOPA homovanillic acid |
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