维持性血液透析患者头孢菌素脑病7例临床分析

目的：了解维持性血液透析患者头孢菌素脑病的临床特点。方法：回顾性分析2004年4月-2012年1月我院维持性血液透析患者应用头孢菌素治疗出现的7例头孢菌素脑病的临床特征。结果：所有患者均无神经系统定位体征,血肌酐、尿素氮、电解质、血糖、血气分析、血色素等无异常,经颅脑CT或MRI检查无急性病变。6例患者经停用头孢菌素并行血液灌流治疗后症状完全消失,1例死亡。结论：维持性血液透析患者可发生头孢菌素脑病,治疗中应合理用药。

Clinical Analysis of Maintenance Hemodialysis Patients with Cephalosporin Encephalopathy

Objective：To investigate the clinical characteristics of cephalosporin encephalopathy in maintenance hemodialysis patients. Methods： Patients in maintenance hemodialysis treated with cephalosporin antibiotics, occurred cephalosporin encephalopathy from April 2004 to January 2012 were retrospectively analysed. Results ：7 patients in mainte- nance hemodialysis developed cephalosporin eneephalopathy, all patients had no neurological signs of localization before and after diseases onset, there were no significant difference in serum creatinine, blood urea nitrogen,electrolytes, glucose, blood gas analysis, hemoglobin, and no acute lesions by brain CT/MRI examination. After discontinuation of antibiotics and blood perfusion, 6 patients recovered and 1 patient died. Conclusion：Cephalosporin antibiotics can cause neuropsychiatric symptoms in maintenance hemodialysis patients.