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| 口腔疣状癌差异基因表达分析 | |
| 引用本文： | 唐瞻贵,赵素萍,张雷,李小玲.口腔疣状癌差异基因表达分析[J].口腔颌面外科杂志,2005,15(4):344-348. |
| 作者姓名： | 唐瞻贵 赵素萍 张雷 李小玲 |
| 作者单位： | 1. 中南大学湘雅医院口腔颌面外科 2. 中南大学湘雅医院耳鼻咽喉科,湖南,长沙,410078 3. 中南大学肿瘤研究所,湖南,长沙,410078 |
| 基金项目： | 湖南省自然科学基金资助课题（03JJY3045） |
| 摘 要： | 目的:研究口腔疣状癌患者癌组织与正常口腔黏膜上皮组织基因的差异表达。方法:应用 cDNA 芯片技术对4例口腔疣状癌患肯的疣状癌组织及其正常口腔黏膜上皮组织的 mRNA 进行检测。结果:在3900条基因中共发现差异表达基因371条,差异表达基因占9.5%,其中表达增强200条(显著增强56条),表达降低171条(显著降低43条)。结论:口腔疣状癌的发生涉及多基因改变,cDNA 芯片技术能高效研究多个基因的表达水平。 |
| 关 键 词： | 口腔疣状癌 cDNA 芯片 基因表达谱 |
| 文章编号： | 1005-4979（2005）04-0344-05 |
| 收稿时间： | 2005-07-04 |
| 修稿时间： | 2005年7月4日 |
Gene Expression Profile Changes in Oral Verrucous Carcinoma |
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| TANG Zhan-gui,ZHAO Su-ping,ZHANG Lei,LI Xiao-ling.Gene Expression Profile Changes in Oral Verrucous Carcinoma[J].Chinese Journal of Oral and Maxillofacial Surgery,2005,15(4):344-348. | |
| Authors: | TANG Zhan-gui ZHAO Su-ping ZHANG Lei LI Xiao-ling |
| Institution: | 1. Department of Oral and Maxillofacial Surgery, 2. Department of Otorhinolaryngology, Xiangya Hospital, Central South University, Changsha 410078; 3. Cancer Research Institute, Central South University, Changsha 410078 ,Hunan Province, China |
| Abstract: | Objective:To investigate the differences in the gene expression between human oral verrucous carcinoma (OVC)and normal oral mucoas epithelial tissues(OVCN).Methods:cDNA chip was used to detect the mRNA of cancer tissue from 40VC and its normal oral mucous epithelial tissue.Results:Of the 3900 genes,371 different expression genes were found.The rate of different genes was 9.5%,of which the expression of 200 genes was higher(with 56 genes significantly higher)and 171 genes lower(with 43 genes significantly lower)in OVC tissues than that in the normal oral mueous.Conclusion:Many genes may be involved in the pathogenesis of OVC.eDNA chip technology is an effective tool in the study of tumor related genes. |
| Keywords: | oral verrucous carcinoma cDNA chip genes expression profile |
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