Smith-Magenis syndrome: a case report of improved sleep after treatment with beta1-adrenergic antagonists and melatonin |
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| Authors: | Carpizo Rosario Martínez Angeles Mediavilla Dolores González Mónica Abad Araceli Sánchez-Barceló Emilio J |
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| Affiliation: | Unit of Sleep Disorders, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria, Herrera Oria s/n, 39011 Santander, Spain. |
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| Abstract: | ![]()
This report describes the case of a 4-year-old boy diagnosed with Smith-Magenis syndrome in whom treatment with a beta(1)-adrenergic antagonist in the morning (to suppress the diurnal melatonin secretion) and melatonin in the evening (to generate a nocturnal peak of melatonin) improved his sleep quality, evaluated by polysomnographic studies. |
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| Keywords: | REM, Rapid eye movement SMS, Smith-Magenis Syndrome TST, Total sleep time |
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