|
|||||
|
|
Evidence from 32P-postlabeling and the use of pentachlorophenol for a novel metabolic activation pathway of diethylstilbestrol and its dimethyl ether in mouse liver: likely {alpha}-hydroxylation of ethyl group(s) followed by sulfate conjugation |
|
| Authors: | Moorthy, Bhagavatula Liehr, Joachim G. Randerath, Erika Randerath, Kurt |
| Affiliation: | Division of Toxicology, Department of Pharmacology, Baylor College of Medicine Houston, TX 77030 1Department of Pharmacology and Toxicology, University of Texas Medical Branch Galveston, TX 77550, USA |
| Abstract: | Diethylstilbestrol (DES), a synthetic stilbene estrogen, isa potent developmental toxin and carcinogen in humans and rodents.A number of 32P-postlabeling studies suggest that genotoxiceffects of DES substantially contribute to these biologicaleffects. The mechanisms involved in DES-mediated genotoxicityare not completely understood, however. As reported here, thestructural resemblance of tamoxifen to DES led to the hypothesisthat DES may be hydroxylated and sulfated at the allylic C2and/or C5 of the ethyl side chains in analogy to |
| Keywords: | |
| 本文献已被 Oxford 等数据库收录！ | |