首页 | 本学科首页   官方微博 | 高级检索  
     


Two four-marker haplotypes on 7q36.1 region indicate that the potassium channel gene HERG1 (KCNH2, Kv11.1) is related to schizophrenia: a case control study
Authors:Fatmahan?Atalar  mailto:atalarf@istanbul.edu.tr"   title="  atalarf@istanbul.edu.tr"   itemprop="  email"   data-track="  click"   data-track-action="  Email author"   data-track-label="  "  >Email author,Tufan?Tevfik?Acuner,Naci?Cine,Fatih?Oncu,Dogan?Yesilbursa,Ugur?Ozbek,Solmaz?Turkcan
Affiliation:(1) Endocrinology Laboratory, Department of Growth, Development and Pediatric Endocrinology, Child Health Institute, Istanbul University, Istanbul, Turkey;(2) Department of Genetics, Institute of Health Sciences, Istanbul University, Istanbul, Turkey;(3) Department of Medical Genetics, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey;(4) Psychiatry Clinics, Turkish Ministry of Health Bakirkoy Research and Training Hospital for Psychiatry, Neurology and Neurosurgery, Istanbul, Turkey;(5) Department of Genetics, Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey
Abstract:

Background  

The pathobiology of schizophrenia is still unclear. Its current treatment mainly depends on antipsychotic drugs. A leading adverse effect of these medications is the acquired long QT syndrome, which results from the blockade of cardiac HERG1 channels (human ether-a-go-go-related gene potassium channels 1) by antipsychotic agents. The HERG1 channel is encoded by HERG1 (KCNH2, Kv11.1) gene and is most highly expressed in heart and brain. Genetic variations in HERG1 predispose to acquired long QT syndrome. We hypothesized that the blockade of HERG1 channels by antipsychotics might also be significant for their therapeutic mode of action, indicating a novel mechanism in the pathogenesis of schizophrenia.
Keywords:
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号