急性与亚急性重症肝炎的内毒素血症及治疗

本文观察了我科自1987年3月～1990年6月收治的58例急性、亚急性重症肝炎的内毒素血症对疾病的发生、发展及预后估计的作用。结果表明,内毒素血症在急性肝炎的发生率是50％,重症肝炎为100％,而且重症肝炎的内毒素水平高于急性肝炎,内毒素水平大于与小于250pg/ml两组,病死与存活率有非常显著性差异。内毒素水平与PT延长秒、Fn、Lpo水平有关。肝功能损害形成了内毒素血症,内毒素血症加重了肝功能损害,形成了恶性循环。阻断恶性循环,抗内毒素血症治疗是重要的一部分。我们采用了“重肝Ⅰ号”治疗,取得了较满意的效果。

Endotoxemia in Acute and Subacute Severe Hepatitis and Its Treatment

Fifty eight cases of acute and subacute fulminant hepatitis admitted in this hospital from March 1987 to June 1990 were observed. Endotoxemia were discovered in 50% of cases of acute hepatitis and in 100% of fulminant hepatitis. Endotoxemia was more prominent in fulminant hepatitis than in acute hepatitis and among the patients with fulminant hepatitis endotoxemia was more prominent in the fatal group. Plasma endotoxin and PT, Fn, Lpo levels were closely correlative. Endotoxemiamight play an important role in the liver demage. Herbal medicine was used in trea-ting patients with endotoxemia with encouraging results.