祛风化痰、肺鼻同治法治疗鼻后滴流综合征240例临床疗效观察

目的 观察祛风化痰、肺鼻同治法治疗鼻后滴流综合征的临床疗效.方法 将确诊为鼻后滴流综合征且属风痰留恋、肺鼻不利证的360例患者,随机分为治疗组240例、对照组120例.治疗组予中药川芎茶调散合苍耳子散加减治疗,对照组予西药美敏伪麻溶液治疗,疗程均为7d.比较2组中医证候疗效、症状积分变化及复发情况.结果 治疗组240例中,临床痊愈32例（13.30％）,显效83例（34.58％）,有效103例（42.92％）,无效22例（9.17％）,总有效率为90.83％;对照组120例中,临床痊愈7例（5.83％）,显效31例（25.83％）,有效56例（46.67％）,无效26例（21.67％）,总有效率为78.33％.经Ridit分析,U=3.63,P=0.00049,P＜0.05,说明治疗组疗效优于对照组.2组治疗前咳嗽、咳痰、咽痒、鼻涕、鼻塞积分比较差异均无统计学意义（P＞0.05）.治疗后治疗组咳嗽、咳痰、咽痒、鼻涕、鼻塞积分较对照组降低明显,差异均有统计学意义（P＜0.05）,治疗组优于对照组.停药后2周对2组临床痊愈、显效、有效病例进行随访,治疗组共218例,复发29例,复发率为13.30％,对照组共94例,复发26例,复发率为27.66％,治疗组复发率低于对照组（P＜0.05）.结论 祛风化痰、肺鼻同治法治疗鼻后滴流综合征风痰留恋、肺鼻不利证有较好的疗效,且停药后复发率较低.

Curative effects of therapies of dispelling wind and resolving phlegm,and treating both lung and nose on postnasal drip syndrome in 240 cases

Objective To observe the curative effects of therapies of dispelling wind and resolving phlegm, and treating both lung and nose on postnasal drip syndrome （PNDS）. Methods The patients （n=360） were randomly divided into treatment group （n=240） and control group （n=120）. Treatment group was treated with Chuanxiong Chatiao San and Cang＇ erzi San for 7 d, and control group, Pseudoephedrine Hydrochloride Oral Solution for 7 d. The curative effects on TCM syndromes, changes of symptom integrals and PNDS relapse were compared between two groups. Results Among 240 cases in treatment group, there were 32 （13.30%） cured, 83 （34.58%） with significant curative effect, 103 （42.92%） with curative effect, and 22 （9.17%） without curative effect, and the total effective rate was 90.83%. Among 120 cases in control group, there were 7 （5.83%） cured, 31 （25.83%） with significant curative effect, 56 （46.67%） with curative effect, and 26 （21.67%） without curative effect, and the total effective rate was 78.33%. Ridit analysis showed that U=3.63, P=0.00049, P〈0.05. The difference in symptom integrals had no statistical significance between two groups before treatment （P〉0.05）, and the integrals were lower in treatment group than those in control group after treatment （P〈0.05）. After stopping treatment for 2 weeks, the cured patients and those with curative effect in two groups were followed up. Of 218 cases in treatment group, there were 29 （13.30%） had recurrent PNDS, and of 94 cases in control group, there were 26 （27.66%） had recurrent PNDS （P〈0.05）. Conclusion The therapies of dispelling wind and resolving phlegm, and treating both lung and nose have better curative effect on PNDS, and recurrent rate is lower after stopping treatment.