调节性T细胞与原发性肝癌的免疫治疗

原发性肝癌的免疫治疗近年来发展迅速,在基础和临床前期研究中取得了令人鼓舞的治疗成果.但和其它恶性肿瘤类似,肝癌存在着严重的肿瘤免疫微环境抑制,大大影响了肝癌免疫治疗的效果.调节性T细胞(Treg)是一类免疫负性调控细胞,在维持人体自身免疫稳定和抗肿瘤免疫过程中起着重要作用,是形成肿瘤免疫微环境抑制的重要机制之一.有关Treg同肝癌的研究表明,Treg有可能成为肝癌免疫治疗的潜在靶点.

Regulatory T cells and immunotherapy of primary hepatocellular carcinoma

Immunotherapy of hepatocellular carcinoma(HCC)develops rapidly in recent years and has yielded encouraging results in both experimental and pre-clinical studies.However,similar to other malignant tumors,there exists serious immune suppression in HCC tumor microenvironment,which significantly affected the therapeutic effect of HCC immunotherapy.Regulatory T cells(Treg)are a group of immune negative regulation cells.It plays an important role in maintaining the homeostasis of the immune system and is one of the most important mechanisms of immune microenvironment suppression.Studies concerning Treg and HCC indicate that Treg might be the potential target for HCC immunotherapy.