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Deregulation of base excision repair gene expression and enhanced proliferation in head and neck squamous cell carcinoma |
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| Authors: | Ishrat Mahjabeen Kashif Ali Xiaofeng Zhou Mahmood Akhtar Kayani |
| Affiliation: | 1. Cancer Genetics Lab, Department of Biosciences, COMSATS Institute of Information and Technology, Park Road Chakshazad, Islamabad, Pakistan 2. Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USA 3. Department of Periodontics, College of Dentistry, Graduate College, UIC Cancer Center, University of Illinois at Chicago, Chicago, IL, USA |
| Abstract: | Defects in the DNA damage repair pathway contribute to cancer. The major pathway for oxidative DNA damage repair is base excision repair (BER). Although BER pathway genes (OGG1, APEX1 and XRCC1) have been investigated in a number of cancers, our knowledge on the prognostic significance of these genes and their role in head and neck squamous cell carcinoma is limited. Protein levels of OGG1, APEX1 and XRCC1 and a proliferation marker, Ki-67, were examined by immunohistochemical analysis, in a cohort of 50 HNSCC patients. Significant downregulation of OGG1 (p?p?p?p?r?=?0.33, p?r?=??0.377, p?r?=??0.435, p?r?=??0.34, p?p?p?p?p? |
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