韩氏穴位神经刺激仪对大鼠佐剂性关节炎的治疗作用

以佐剂性关节炎大鼠作为病理性疼前的实验动物模型，用韩氏穴位神经刺激仪进行治疗，结果发现：关节炎大鼠痛阈较正常鼠明显降低，体温及患肢直径也明显增加；但经过一个疗程治疗后，关节炎大鼠的症状有明显的改善，表现为痛阈显著提高，体温恢复正常和患肢肿胀程度减轻；腹腔注射维生素Ｂ６能显著加强治疗的镇痛作用。结果表明：佐剂性关节为大鼠可作为病理性疼痛的实验动物模型；韩氏穴位神经刺激仪对关节炎大鼠上有良好的治疗作用

HAN''S ACUPOINT NERVE STIMULATOR(HANS)FOR THE TREATMENT OF ADJUVANT ARTHRITIS IN RATS

Rats with adjuvant arthritis were used as an animal model of pathological pain inthis experiment and pain threshold was examined by recording the latency of heat -tail flickreflex- The results were as follows:The pain threshold decreased significantly , body temperature and the diameter of the ankle joint of hind leg increased remarkably post inoculation After HAN treatment,the pain threshold increased, while body temperature and the joint diameter decreased significantly The analgesic effect of HAN was enhanced by intraperitoneal injection of Vitamin B6. The results suggest that the adjuvant arthritis could be used as agood model for the study of chronic pain, and HANS did show a good therapeutic effect onadjuvant arthritis in rats,which seemed to be improved by the injection of Vitamin B6.