| 硝西泮中一种未知杂质的结构确证 |
| |
| 引用本文： | 刘菁,蔡梅,王玉,李华龙.硝西泮中一种未知杂质的结构确证[J].天津药学,2017(2):1-5. |
| |
| 作者姓名： | 刘菁 蔡梅 王玉 李华龙 |
| |
| 作者单位： | 1. 天津市药品检验研究院,天津,300070;2. 江苏省食品药品监督检验研究院,南京,210008 |
| |
| 摘 要： | 目的: 对硝西泮原料药中一种未知杂质进行结构确证.方法: 应用HPLC-MS/MS、核磁共振(1H-NMR、13C-NMR) 技术,对硝西泮原料药中一种未知杂质进行结构分析.结果: 首次发现并确定硝西泮未知杂质的结构.结论: 该方法可为硝西泮的质量控制提供依据.
|
| 关 键 词： | 硝西泮 未知杂质 LC-MS/MS NMR |
Structural determination of an unknown impurity in nitrazepam |
| |
| Liu Jing,Cai Mei,WangG Yu,Li Hualong.Structural determination of an unknown impurity in nitrazepam[J].Tianjin Pharmacy,2017(2):1-5. |
| |
| Authors: | Liu Jing Cai Mei WangG Yu Li Hualong |
| |
| Abstract: | Objective: To establish a method for the determination of the chemical structure of an unknown impurity in nitrazepam. Methods: HPLC-MS/MS and nuclear magnetic resonance(1H-NMR,13C-NMR) were adopted for determination of the chemical structure of an unknown impurity in nitrazepam. Results: The chemical structure of the unknown impurity was determined and identified.Conclusion: The established method can provide a complete solution for quality control of nitrazepam. |
| |
| Keywords: | nitrazepam impurity NMR HPLC-MS/MS |
| 本文献已被 万方数据 等数据库收录！ |
|
