从天人相应到光-MT生物信号转导周期网络:一个关于生命衰老动因的统一理论--补肾方药(杞蓉益精颗粒)对小鼠光-Melatonin生物信号转导周期调谐作用的实验研究

以往的研究虽然已经提出了许多关于生命衰老的理论或学说,但至今还没有建立起一个统一的理论。基于中医学的天人相应衰老说,根据有关光周期信号和Melatonin(MT)化学周期信号相互转导的研究结果,综合已有的衰老理论,首次提出并阐释了生命衰老的光-MT生物信号转导周期网络(PeriodNetworkofLight-MTBiosignalTransduction,PNLMBT)理论。在机体的不同水平,存在着一个由太阳光周期信号启动并与其相谐振的PNLMBT。该网络间相互作用的非线性动力学过程及其状态是决定生命非自然衰老的根本动因和机制。这一理论不仅能将已有的各种生命非自然衰老的理论或学说统一起来,对生命的非自然老化现象做出很好的解释,而且可以为人们寻找延缓衰老的方法提供新的思路。以这一理论为基础,观察了中医补肾方药(杞蓉益精颗粒)对小鼠光-MT生物信号转导周期的“调谐”作用。这一实验结果为PNLMBT理论提供了初步的实验支持,也为进行“调谐”PNLMBT运行生物活性物质的筛选提供了进一步的研究方向。

From Correspondence Between Man and Universe to the Period Network of Light-MT Biological Transduction: Experimental Study of Qirong Yijing Granule to Light and Melatonin Biosignal Transduction Period

No unified theory has been set up yet though a lot of theories on senility have been put forward to in the past researches. New theory of senility period network of light-MT biosignal transduction(PNLMBT) was put forward to and explained for the first time in this article based on TCM theory of correspondence between man and universe senility, and other senility theories, together with the study of period network of light and biosignal transduction. PNLMBT activated by and resonating with the sun photoperiod signal exists on different levels of the body. The course and state of the interactive nonlinear kinetics in the network are the reason and mechanism of unnatural senility. This theory does not only unify the other life unnatural senility theories, and make a good explanation for it, but also offers new way of thinking for slowing aging. The“adjusting”effect of Qirong Yijing granule on light and melatonin biosignal transduction period was observed in this experiment on the basis of this theory. The experimental result has offered the preliminary experimental proof for PNLMBT theory, and the further research direction for selecting biological active material.