| Tumor-associated macrophages regulate gastric cancer cell invasion and metastasis through TGFβ2/NF-κB/Kindlin-2 axis |
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| 作者姓名： | Zhu Wang Yang Yang Yancheng Cui Chao Wang Zhiyong Lai Yansen Li Wei Zhang Harri Mustonen Pauli Puolakkainen Yingjiang Ye Kewei Jiang Zhanlong Shen Shan Wang |
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| 作者单位： | 1. Department of Gastroenterological Surgery, Peking University People's Hospital;2. Laboratory of Surgical Oncology,Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People's Hospital;3. Department of Surgery, Helsinki University Central Hospital, and University of Helsinki |
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| 基金项目： | supported by grants from the National Natural Science Foundation of China (No. 81372291); |
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| 摘 要： | Objective: Recent studies have shown that tumor-associated macrophages(TAMs) play an important role in cancer invasion and metastasis. Our previous studies have reported that TAMs promote the invasion and metastasis of gastric cancer(GC) cells through the Kindlin-2 pathway. However, the mechanism needs to be clarified.Methods: THP-1 monocytes were induced by PMA/interleukin(IL)-4/IL-13 to establish an efficient TAM model in vitro and M2 macrophages were isolated via flow cytometry. A dual lucife...
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