Subcellular distribution of gallium-67 in tumor and liver |
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| Affiliation: | 1. Schools of Paramedicine, Kanazawa University, 5-11-80 Kodatsuno Kanazawa City 920, Japan;2. Medicine, Kanazawa University, 5-11-80 Kodatsuno Kanazawa City 920, Japan;3. Medical College of Oita, Oita, Japan;1. Anaesthesia and Intensive Care, Department of Clinical Sciences, Lund, Lund University, Lund, Sweden;2. Department of Cardiothoracic Surgery, Anaesthesia and Intensive Care, Skåne University Hospital, Lund, Sweden;3. Medical Faculty, Lund University, Lund, Sweden;4. Department of Anaesthesia and Intensive Care, Helsingborg Hospital, Helsingborg, Sweden;5. Department of Anaesthesia and Intensive Care, Kristianstad Hospital, Kristianstad, Sweden;6. Department of Intensive and Perioperative Care, Skåne University Hospital, Malmö, Sweden;7. Department of Intensive and Perioperative Care, Skåne University Hospital, Lund, Sweden;1. Department of Physics, Govt. General Degree College, Salboni, Paschim Medinipur 721516, India;2. Physical Analysis Lab, Mineral Exploration Corporation Limited, Nagpur 440006, India;3. Department of Physics, The University of Burdwan, Burdwan 713104, India |
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| Abstract: | Subcellular distribution of 67Ga was quantitatively determined to evaluate the role of the lysosome in accumulation of 67Ga in malignant tumor tissue and the liver using three different tumor models and the host liver. In Yoshida sarcoma and Ehrlich tumor, most of the radioactivity of 67Ga was localized in the supernatant fraction, and only a small amount of radioactivity was localized in the mitochondrial fraction, which contains lysosomes. In the liver, however, most of the radioactivity was concentrated in the mitochondrial fraction. The radioactivity of this fraction increased with time after the administration of 67Ga and reached approximately 50% of total radioactivity within 24 h. In the case of hepatoma AH 109A, radioactivity of the mitochondrial fraction increased with time after administration, and about 30%, of total radioactivity was concentrated in this fraction after 24 h. It is concluded that lysosome does not play a major role in the tumor concentration of 67Ga, although it may play an important role in the liver concentration of 67Ga. In the case of hepatoma AH109A, it is presumed that lysosome plays a considerably important role in the tumor concentration of 67Ga, hepatoma AH 109A possessing some residual features of the liver. |
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