复方甘草酸苷治疗女性青春期后痤疮疗效观察

目的：评价复方甘草酸苷治疗女性青春期后痤疮的有效性、安全性，并探讨其作用机理。方法：49例女性青春期后痤疮患者随机分为两组。治疗组27例，口服复方甘草酸苷片；对照组22例，口服安体舒通片。两组患者在口服药物的同时均外用5％硫磺霜。疗程均为8周。于用药前、用药后2、4、8周末分别观察记录面部各种皮损的实际数目、全身及局部不良反应。并分别在用药前、用药后8周检测血清睾酮（T）、雌二醇（E2）及胰岛素样生长因子1（IGF-1）水平。结果：治疗4周后两组平均皮损数目分别由50.2±11．54、48．5±12．26减少为17，8±9．54、38．9±10，64（P〈0．05），复方甘草酸苷起效比安体舒通快；治疗8周后两组有效率分别为85．2％、68．2％（P〉0．05），二者总体疗效相当；复方甘草酸苷治疗女性青春期后痤疮复发率低、无明显不良反应。实验室结果显示，治疗组患者的血清T和IGF-1水平分别由78．4±32．93ng／dL、338．6±91．58ng／mL下降为36．5±13．91ng／dL（P〈0．01）、196．6±60．95ng／mL（P〈0．05），但复方甘草酸苷对E2水平的影响不大。结论：复方甘草酸苷是治疗女性青春期后痤疮安全、有效的方法，并有调节患者血清T及IGF-1水平的作用。

Clinical efficacy and safety of compound glycyrrhizin in the treatment of post-adolescent acne in women

Objective：To assess the therapeutic efficacy and satety and investigate me mechanism of Compound Glycyrrhizin in the treatment of post - adolescent acne in women. Methods ：49 female patients with post - adolescent acne were randomly divided into two groups ： The trial group （n = 27） and control group （n = 22）. Patients of the trial group were treated with tablet of Compound Glycyrrhizin, and the control group received spironolactone. 5% sulphur cream was locally applied onto the eruptions for all patients. The course of treatment in the two groups lasted 8 weeks. The number of lesions and adverse reactions were recorded before the therapy and at week 2, 4, 8 during the therapy. The serum concentrations of testosterone （T）, estradiol （E2） and insulin - like growth factor - 1 （ IGF - 1 ） levels were detected before and after treatment, respectively. Results：The mean number of lesions decreased from 50. 2 ± 11.54,48.5 ± 12.26 to 17. 8 ±9.54,38.9 ± 10. 64 in trial group and control group（P 〈0.05）, respectively at week 4. Compound Glycyrrhizin worked faster than spironolactone. The overall effective rate was 85.2% in trial group and 68.2% in control（ P 〉 0. 05 ） after the therapy, respectively, the therapeutic effectiveness was equivalent in two groups. In trial group, recurrence rate was lower and no major ad- verse reactions were encountered. The serum concentrations of T and IGF - 1 levels decreased from78.4 ±32.93ng/dl,338.6 ±91.58ng/mlto36.5 ± 13.91ng/dl（P 〈0.01 ） ,196.6 ±60. 95 ng/ml（P 〈 0. 05）in trial group, while Compound Glycyrrhizin does not intluence the levex of E2. Conclusion： Compound Glycyrrhizin was safe and effective in the treatment of female postadolescent aene and it had regulative effects on serum T and IGF - 1 levels in women with postadolescent acne.