| 反相高效相色谱法测定马沙拉嗪的含量 |
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| 引用本文： | 周晶,王效山,刘修树,赵煤矿,吴虹. 反相高效相色谱法测定马沙拉嗪的含量[J]. 中南药学, 2008, 6(1): 72-73 |
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| 作者姓名： | 周晶 王效山 刘修树 赵煤矿 吴虹 |
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| 作者单位： | 安徽中医药大学药学院,合肥,230038 |
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| 摘 要： | 目的 建立反相高效液相色谱法测定马沙拉嗪的含量。方法 采用Hypersil C18（4．6mm×250mm，5μm）色谱柱，流动相为甲醇-水溶液（60：40），检测波长为210nm，进样体积20μL。结果马沙拉嗪在5～300μg·mL^-1，线性关系良好（r＝o．9999）。结论 该法的专属性强，用于马沙拉嗪含量测定，准确可靠。
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| 关 键 词： | 马沙拉嗪 反相高效液相色谱 含量测定 |
| 文章编号： | 1672-2981（2007）06-0072-02 |
| 收稿时间： | 2007-01-05 |
| 修稿时间： | 2007-06-20 |
Determination of mesalazine by RP-HPLC |
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| ZHOU Jing,WANG Xiao-shan,LIU Xiu-shu,ZHAO Mei-kuang,WU Hong. Determination of mesalazine by RP-HPLC[J]. Central South Pharmacy, 2008, 6(1): 72-73 |
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| Authors: | ZHOU Jing WANG Xiao-shan LIU Xiu-shu ZHAO Mei-kuang WU Hong |
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| Affiliation: | (Anhui College of Traditional Chi nese Medicine, Hefei 230038) |
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| Abstract: | Objective To establish an RP-HPLC method to detenmine the content of mesalazine. Methods The sample was quantified by an RP-HPMC, which was equipped with a Hypersil C18 column （4. 6 mm× 250 mm, 5μm）. Methonal-H2O （60 ： 40） was used as the mobile phase, the flow rate was 1, 0 mL · min^-1 , and the wave length was 210 nm. Results The method showed a good linearity for mesalazine in the range of 5～300 μg · mL^-1 （r=0. 999 9）. Conclusion The method showed spelificity with high precision. It is effective for determining the content of mesalazine. |
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| Keywords: | mesalazine RP-HPLC content determination |
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