| 肾乐冲剂对阿霉素肾病大鼠血清TNF、IL-8水平的干预作用 |
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| 引用本文： | 王海云,石君杰,盛丽先. 肾乐冲剂对阿霉素肾病大鼠血清TNF、IL-8水平的干预作用[J]. 中国中医药信息杂志, 2003, 10(5): 18-19 |
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| 作者姓名： | 王海云 石君杰 盛丽先 |
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| 作者单位： | 1. 浙江省立同德医院,杭州,310012
2. 浙江中医学院 |
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| 摘 要： | 目的：观察肾乐冲剂对阿霉素肾病大鼠的疗效及其对血清THF、IL—8水平的干预作用。方法：采用Bertani的方法复制阿霉素(ADR)肾病大鼠模型。灌服不同剂量肾乐冲剂和／或强的松混悬液，测定大鼠24h尿蛋白定量，测定血清ALB、CHOL、TG、THF、IL—8的含量，并进行电镜下肾脏超微结构学检查。结果：肾乐冲剂可减少阿霉素肾病大鼠尿蛋白的排泄量，提高血清白蛋白水平，降低血清脂质水平和血清THF、IL—8的水平，修复肾小球上皮细胞足突的结构。结论：肾乐冲剂对阿霉素肾病大鼠有明显疗效，并能改善其免疫功能，为临床治疗小儿原发性肾病综合征提供了理论依据。
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| 关 键 词： | 肾乐冲剂 阿霉素 肾病 大鼠 血清 TNF IL－8 干预作用 强的松混悬液 尿蛋白 肿瘤坏死因子 |
| 修稿时间： | 2002-09-16 |
Experimental Research on Shenle Powder in Improving TNF、 IL-8 of ADR Nephrosis Rats |
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| Wang Haiyun,Shi Junjie,Sheng Lixian. Experimental Research on Shenle Powder in Improving TNF、 IL-8 of ADR Nephrosis Rats[J]. Chinese Journal of Information on Traditional Chinese Medicine, 2003, 10(5): 18-19 |
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| Authors: | Wang Haiyun Shi Junjie Sheng Lixian |
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| Abstract: | Objective : To explore the effect and mechanism of Shenle powder in treating pediatric PNS. Methods: Induce MCN model with ADR by venoclysis through caudal vein, feed them with Shenle powder and/or predisone suspension, then observe the amount of protein in urine, ultrastructure change in kidneys, determine the ALB, CHOL, TG, TNF, IL-8 in serum. Results : Shenle powder can decrease the amount of protein in urine, promote the level of ALB and lower the CHOL, TG, TNF, IL-8 in serum, repair injuryed podocytic process of glomerulus epithelical cell. Conclusions : Shenle powder has obvious protective effect to ADR nephrosis rats, strengthen immunologic function. It provides the oretic proofs in treating and preventing pediatric PNS. |
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| Keywords: | Shenle powder ADR nephrosis TNF: IL-8 |
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