| 吲哚胺2,3双加氧酶与肿瘤免疫耐受 |
| |
| 引用本文： | 卜晓倩.吲哚胺2,3双加氧酶与肿瘤免疫耐受[J].国际肿瘤学杂志,2010,37(4). |
| |
| 作者姓名： | 卜晓倩 |
| |
| 作者单位： | 山西医科大学第二医院消化内科,太原,030012 |
| |
| 摘 要： | 调节性T细胞(Treg)介导的克隆抑制,是引起肿瘤免疫耐受的主要因素之一.而吲哚胺2,3双加氧酶(IDO)通过对Treg细胞的作用下调各系统肿瘤微环境中的免疫反应,从而诱导宿主免疫耐受的形成.IDO抑制剂1-MT将有望成为治疗肿瘤的新靶点.
|
| 关 键 词： | 肿瘤 免疫耐受 吲哚胺-吡咯2 3-双加氧酶 CD4+CD25+T细胞 |
Indoleamine 2,3-dioxygenase and immune tolerance in tumor |
| |
| BU Xiao-qian.Indoleamine 2,3-dioxygenase and immune tolerance in tumor[J].Journal of International Oncology,2010,37(4). |
| |
| Authors: | BU Xiao-qian |
| |
| Abstract: | Clonal suppression induced by CD4+ CD25+ regulatory T cells is one of the principal factors to evoke the immune tolerance in tumor. Through the activation of CD4+ CD25+ regulatory T cells, the indoleamine 2,3-dioxygenase (IDO) reduces the immune response in tumor micro-environment of various systems , and induces the formation of host immune tolerance. IDO inhibitor 1-MT is expected to become a new target for cancer treatment. |
| |
| Keywords: | Neoplasms Immune tolerance Indoleamine-pyrrole 2 3-dioxygenase CD4+ CD25+ T cells |
| 本文献已被 万方数据 等数据库收录！ |
|
