鼻咽癌微血管与远处转移关系的初步研究

目的 研究肿瘤血管参数改变在鼻咽癌远处转移中的及其评价预后的作用；并由此探讨抗篾这生成治疗预防鼻咽癌远处转移的可能性。方法 选择５２例初治转移鼻咽癌，与另５２例初治无转移且长期无瘤生存的鼻咽癌在性别、年龄、Ｔ分期和Ｎ分期方面进行一对一配对，取其组织进行微血管的免疫组化染色和计算机图象分析，配对比较４个参数；微血管计数、微血管相对面积、平均血管面积和平均血管周长。并分析这些参数在各型转移鼻咽癌中的差

Preliminary study on the correlation between neovasculature and metastatic nasopharyngeal carcinoma by computer image analysis]

OBJECTIVE: To investigate the significance of neoangiogenesis in metastasis of nasopharyngeal carcinoma (NPC) so as to clarify further the role of neovascularity in evaluating the prognosis of NPC and the probability of antiangiogenesis in preventing distant metastasis of NPC. METHODS: Fifty-two patients with metastatic NPC were selected and strictly matched in sex, age, T stage, and N stage with another 52 patients with non-metastatic NPC and survived a long time. The tumor tissues of all 104 patients were retrived for computer-assisted, immunohistochemical analysis of tumor vasculature. RESULTS: Counts of microvessel and relative area of all microvessels per image were significantly higher in metastatic NPCs than those of curable, non-metastatic NPCs; while average area of microvessel and average perimeter of microvessel in metastatic NPCs were smaller than those of the opposite. No significant difference in any microvessel parameter had been found among various types of metastasis. CONCLUSIONS: The alterations of microvessel parameters bore significant relationships with metastases of NPC. Evaluation of neovascularity with computer image analysis may help in estimating the prognosis of NPC and in finding out the indications for aggressive multimodal treatments. Angiogenesis inhibitors might be helpful in preventing NPC from distant metastasis.