Pharmacokinetics and tissue distribution of liposomal etoposide in rats

Precipitation of etoposide and adverse events associated with the co-solvents in intravenous solutions can be avoided by using liposomal etoposide (LE). The pharmacokinetics and distribution of the commercial formulation (ETPI) and LE were compared in rats. The pharmacokinetic profiles were biphasic and similar in the initial phase (C_max, Vd, and t_1/2α). However, LE showed a 60% increase in AUC with a 35% decrease in clearance (p?