Aspirin inhibits hepatitis C virus entry by downregulating claudin‐1 |
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| Authors: | P Yin L Zhang |
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| Institution: | MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China |
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| Abstract: | Aspirin has previously been reported to inhibit hepatitis C virus (HCV) replication. The aim of this study was to investigate whether aspirin is involved in blocking HCV entry. We found that aspirin inhibits the entry of HCVpp and infectious HCV. The level of claudin‐1, an HCV receptor, is reduced by aspirin. Our results extend the anti‐HCV effect of aspirin to the HCV entry step and further reinforce the anti‐HCV role of aspirin. |
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| Keywords: | aspirin claudin‐1 hepatitis C virus entry |
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