老年男性2型糖尿病患者骨密度与冠心病的相关性

目的探讨老年男性2型糖尿病患者骨密度与冠心病的相关性。方法102例老年男性2型糖尿病住院患者根据是否合并冠心病分两组,比较分析两组患者的腰1～腰4及右侧股骨颈的骨密度）,并采用多因素非条件Logistic回归分析骨质疏松与冠心病的相关性。结果合并冠心病组腰1～腰4和股骨颈的骨密度分别为（0．73±0．12）g／cm^2、（0．76±0．14）g／cm^2、（0．82±0．22）g／cm^2、（0．81±0．21）g／cm^2、（0．71±0．12）g／cm^2,未合并冠心病组骨密度分别为（0．86±0．17）g／cm^2、（0．92±0．22）g／cm^2、（0．96±0．23）g/cm^2、（0．98±0．25）g／cm^2、（0．80±0．13）g／cm^2,两组比较,差异均有统计学意义（t分别：-4．38、-4．32、-3．27-3．67、-4．30,P均〈0．05）。调整了年龄、体重指数、血脂、血钙、血磷后,经Logistic回归分析显示：骨质疏松和冠心病存在明显的相关性（OR=3．80,95％CI：1．50～9．61,P〈0．05）。结论老年男性2型糖尿病患者骨密度的降低可能跟冠心病的发生、发展有关。

Relationship between bone mineral density and coronary heart diseases in elderly male patients with type 2 diabetic

Objective To assess the relationship between bone mineral density and coronary heart diseases in elderly male patients with type 2 diabetic. Methods Bone mineral density in the lumbar spines（L1-4）and the right femoral neck of 102 type 2 diabetic elderly male patients were measured by dual energy X-ray absorptiometry. Patients were divided into eoronary heart disease group and non coronary heart disease group. Relationship between osteoporosis and coronary heart disease was analyzed by multivariate unconditional logistic regression analysis. Results Bone mineral densities in the lumbar spines （L1-4）and the right femoral neck of patients with coronary heart disease were （0.73 ±0.12） g/cm^2, （0.76±0.14）g/cm^2, （0.82±0.22）g/cm^2, （0.81±0.21 ）g/cm^2, （0.71 ±0.12）g/cm^2; patients without coronary heart disease were （0.86±0.17）g/cm^2, （0.92±0.22）g/cm^2, （0.96±0.23）g/cm^2, （0.98±0.25）g/cm^2, （0.80±0.13）g/cm^2. The differences of bone mineral density between two groups were statistically significant （t=-4.38, -4.32,-3.27,-3.67,-4.30,P〈0.05）. Osteoporosis were related to coronary heart diseases by logistic regression analysis （OR=3.80,95% CI： 1.50-9.61, P〈0.05）, regardless of age, body mass index, plasma lipid, calcium and phosphorus. Conclusions Decrease of bone mineral density in type 2 diabetic elderly male patients may be related to the development of coronary heart diseases.