| 神经生长因子在恒前牙龋源性牙髓炎早期牙痛中的作用 |
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| 引用本文： | 赵梦明 李宏捷 朱晓红 刘颖. 神经生长因子在恒前牙龋源性牙髓炎早期牙痛中的作用[J]. 牙体牙髓牙周病学杂志, 2005, 15(10): 546-549 |
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| 作者姓名： | 赵梦明 李宏捷 朱晓红 刘颖 |
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| 作者单位： | [1]天津医科大学口腔医院,天津300070 [2]天津医科大学口腔病理教研室,天津300070 |
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| 摘 要： | 目的：观察神经生长因子（nerve growth facter，NGF）在正常及炎症组织中的表达和表达差异，探讨其在牙髓炎症和炎性牙痛中的作用。方法：应用免疫组织化学方法和显微图像分析系统，比较NGF在正常和龋源性牙髓炎早期的表达变化，以及观察其与临床牙痛的变化关系，并设一组晚期牙髓炎的牙髓组织作为晚期炎症对照。结果：在正常牙髓中NGF染色呈弱阳性，龋源性牙髓炎早期即呈强阳性表达，晚期牙髓炎亦呈强阳性表达。炎症的发展与伴随此过程的牙齿疼痛症状相符合。结论：NGF伴随着牙髓的炎症变化。由此认为NGF在牙髓炎症及炎性牙痛中发挥重要的作用。
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| 关 键 词： | 神经生长因子 龋齿 牙髓 免疫组织化学 |
| 文章编号： | 1005-2593（2005）10-0546-04 |
| 收稿时间： | 2004-11-01 |
| 修稿时间： | 2005-06-26 |
Changes of nerve growth factor expressing cells in normal and early inflamed dental pulp of carious teeth |
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| ZHAO Meng- ming , LI Hong- jie, ZHU Xiao- hong, LIU Ying. Changes of nerve growth factor expressing cells in normal and early inflamed dental pulp of carious teeth[J]. Chinese Journal of Conservative Dentistry, 2005, 15(10): 546-549 |
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| Authors: | ZHAO Meng- ming LI Hong- jie ZHU Xiao- hong LIU Ying |
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| Affiliation: | Hospital of Stomatology, Tianjin Medical University, Tianjin 300070, China |
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| Abstract: | AIM:To investigate the expression of NGF in human dental pulp tissue,compared with those in aheearly inflamed pulp,and explore the role of NGF in carious pulpitis.METHODS:The expression and distribution of NGF in 20 of inflamed and 10 of normal dental pulp tissue were detected by immunohistochemical technique and observed under optical microscope,then analyzed with the image pattern analytical instrument.The results were statistically analyzed.RESULTS:The expression of NGF was low in the normal pulp group,increased greatly in the pulpitis group(P<0.01).The patient felt tooth pain gradually severe in these stages.CONCLUSION:NGF accompany with the change of pulpal inflammation and dental pain from beginning to end,it may play an important role in this course. |
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| Keywords: | nerve growth factor caries pulp immunohistochemistry |
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