| 3'-大豆苷元磺酸钠对离体心脏缺血再灌注损伤的保护作用 |
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| 引用本文： | 钟富有,肖海,李洪亮,黄志华,何蔚,曾靖.3'-大豆苷元磺酸钠对离体心脏缺血再灌注损伤的保护作用[J].时珍国医国药,2008,19(11). |
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| 作者姓名： | 钟富有 肖海 李洪亮 黄志华 何蔚 曾靖 |
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| 作者单位： | 赣南医学院基础医学院,江西,赣州,341000 |
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| 基金项目： | 国家自然科学基金(No.30560173);;江西省自然科学基金(No.0640003) |
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| 摘 要： | 目的利用离体心脏灌流模型,研究3'-大豆苷元磺酸钠对离体心脏缺血再灌注后损伤的保护作用。方法应用大鼠离体心肌缺血再灌注损伤模型,在灌流液中加入高、低剂量的3'-大豆苷元磺酸钠(0.03,0.01mg/L)。测定冠脉流量、心率、左心室收缩压、左心室舒张压的变化。结果3'-大豆苷元磺酸钠可使缺血再灌注后心脏灌流量增大、左心室收缩压增大、左心室舒张压降低、心率减慢。结论3'-大豆苷元磺酸钠可通过扩张冠脉、减慢心率及增强心肌收缩力对离体心脏缺血再灌注损伤起保护作用。
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| 关 键 词： | 3'-大豆苷元磺酸钠 离体心脏 缺血再灌注损伤 |
Protective Effect of 3'-daidzein Sulfonic Sodium on Isolated Myocardial Ischemia/Reperfusion Injury |
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| ZHONG Fu-you,XIAO Hai,LI Hong-liang,HUANG zhi-hua,HE Wei,ZENG Jing.Protective Effect of 3'-daidzein Sulfonic Sodium on Isolated Myocardial Ischemia/Reperfusion Injury[J].Lishizhen Medicine and Materia Medica Research,2008,19(11). |
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| Authors: | ZHONG Fu-you XIAO Hai LI Hong-liang HUANG zhi-hua HE Wei ZENG Jing |
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| Institution: | Preclinical College;Gannan Medical University;Ganzhou 341000;China |
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| Abstract: | Objective To explore the protective effect of 3'-daidzein sulfonic sodium(DSS) on isolated myocardial ischemia/reperfusion injury.Methods The isolated myocardial ischemia/reperfusion model of rats was made and treated with different doses of DSS(low-dose and high-dose).After that,coronary artery discharge,heart rate,left ventricular systolic pressure and left ventricular diastolic pressure were investigated.Results Dss could increase perfusion volume and left ventricular systolic pressure and decrease left ... |
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