冠心病患者血浆内脂素及基质金属蛋白酶-9的相关性及临床意义 |
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引用本文: | 郭珍奎,贾永平,吕吉元,范春雨,高宇平,王睿. 冠心病患者血浆内脂素及基质金属蛋白酶-9的相关性及临床意义[J]. 中西医结合心脑血管病杂志, 2011, 9(3): 281-283 |
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作者姓名: | 郭珍奎 贾永平 吕吉元 范春雨 高宇平 王睿 |
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作者单位: | 1. 山西医科大学,030001 2. 山西医科大学第一医院,030001 |
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摘 要: | 目的探讨内脂素及基质金属蛋白酶-9(MMP-9)在冠心病(CHD)中的相关性及临床意义。方法选择80例经冠脉造影确诊为冠心病并排除糖尿病的患者和30名健康体检者。冠心病诊断标准为冠状动脉至少一支血管狭窄程度≥50%。将80例CHD患者分为急性冠脉综合征(ACS)组(50例)与稳定型心绞痛(SAP)组(30例)。根据冠脉造影将患者分为单支病变组(26例)、双支病变组(27例)、三支病变组(27例)。以酶联免疫吸附试验法检测80例患者及30例健康对照者血浆内脂素和MMP-9水平。结果 ACS与稳定型心绞痛患者血浆内脂素和MMP-9显著高于对照组(P<0.05),ACS患者血浆内脂素和MMP-9高于与稳定型心绞痛(P<0.05),三支病变组内脂素与MMP-9高于双支病变组(P<0.05),双支病变组高于单支病变组(P<0.05),单支病变组高于对照组(P<0.05)。内脂素水平与MMP-9水平显著正相关(r=-0.763,P<0.05)。结论内脂素、MMP-9与冠心病密切相关,且对冠心病的诊断及预测冠状动脉病变严重程度具有重要临床意义。
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关 键 词: | 冠心病 内脂素 基质金属蛋白酶-9 |
Relation between Plasma Visfatin and Matrix Metalloproteinase-9 in Coronary Heart Disease |
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Affiliation: | Guo Zhenkui,Jia Yongping,Lü Jiyuan,et al Shanxi Medical University(Taiyuan 030001) |
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Abstract: | Objective To explore the relationship between plasma visfatin and matrix metalloproteinase-9(MMP-9) in patients(pts) with coronary heart disease(CHD).Methods Eighty pts with CHD diagnosed by angiography without diabetes mellitus were divided into acute coronary syndrome(ACS) group(n=50) and stable angina pectoris(SAP) group(n=30),and 30 healthy subjects as controls.Pts with CHD were divided into one vessel disease subgroup(n=26),two vessels disease subgroup(n=27),and three vessels disease subgroup(n=27).The... |
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Keywords: | coronary heart disease visfatin matrix metalloproteinase-9 |
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