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| AMH、FSH、E_2在卵巢早衰诊断中的价值 | |
| 引用本文： | 徐琳,任莉,韩雪松,刘攀. AMH、FSH、E_2在卵巢早衰诊断中的价值[J]. 中国优生与遗传杂志, 2011, 0(3): 96-98,29 |
| 作者姓名： | 徐琳 任莉 韩雪松 刘攀 |
| 作者单位： | 昆明医学院第一附属医院妇产科;昆明市延安医院呈贡新区医院外科; |
| 摘 要： | 目的研究顺铂所致化疗损伤性卵巢早衰大鼠血清AMH、FSH、E2水平变化,探讨血清AMH、FSH、E2能否作为评估成年雌性大鼠卵巢储备的早期预测指标。方法通过给成熟雌性SD大鼠腹腔注射生理盐水、4.5mg/kg和6.0mg/kg顺铂,建立大鼠化疗损伤性卵巢早衰模型。检测血清AMH、FSH、E2水平。结果腹腔注射后,大鼠血清AMH水平均明显降低;血清E2水平与对照组相比,低剂量组明显升高,高剂量组无统计学意义,高剂量组与低剂量组相比明显降低;血清FSH水平：低剂量组与对照组相比无统计学意义,高剂量组与对照组、低剂量组相比均升高。腹腔注射前后,各顺铂组血清AMH水平注射后均较注射前明显降低;血清E2水平于注射低剂量顺铂后升高,而注射高剂量顺铂后差异无统计学意义。各顺铂组血清FSH水平注射后均较注射前明显升高。结论顺铂所致的卵巢损害早期血清E2代偿性升高,AMH明显降低,此两种激素的变化早于FSH的变化。血清E2的升高和AMH的降低可以作为暴露于化疗后的卵巢损害的早期预测指标,两者结合起来将有助于早期诊断卵巢早衰。 |
| 关 键 词： | 卵巢早衰 抗苗勒氏管激素 卵泡刺激素 雌二醇 |
The vallue of AMH,FSH,E_2 in POF |
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| XU Lin,REN Li,HAN Xue-song,LIU Pan.. The vallue of AMH,FSH,E_2 in POF[J]. Chinese Journal of Birth Health & Heredity, 2011, 0(3): 96-98,29 | |
| Authors: | XU Lin REN Li HAN Xue-song LIU Pan. |
| Affiliation: | XU Lin,REN Li,HAN Xue-song,LIU Pan.(The First Affiliated Hospital of Kunming Medical College,650032) |
| Abstract: | Obejective: To study the changes of serum AMH,FSH,E2 in rats of cisplatin-induced premature ovarian failure in order to investigate serum AMH,FSH,E2 which can be assessed to the early prediction indicators of ovarian reserve in adult female rats.Methods: Adult female SD rats were treated with saline,4.5mg/kg and 6.0mg/kg cisplatin by intraperitoneal injection to establish successfully in rat model of chemotherapy induced premature ovarian failure.The serum AMH,FSH,E2 were measured.Results: The serum AMH lev... |
| Keywords: | Premature ovarian failure Anti-Müllerian hormone Follicle stimulating hormone Estradiolum |
| 本文献已被 CNKI 维普 等数据库收录！ | |