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| 重组IL2联合LAK和TIL细胞治疗癌性胸腔积液 | |
| 引用本文： | 周桂明 胡青 董卫平 李健远. 重组IL2联合LAK和TIL细胞治疗癌性胸腔积液[J]. 临床肺科杂志, 1997, 2(4): 7-8 |
| 作者姓名： | 周桂明 胡青 董卫平 李健远 |
| 作者单位： | 山东菏泽地区人民医院 274031(周桂明，胡青，董卫平)，山东菏泽地区人民医院 274031(李健远) |
| 摘 要： | 采用自体淋巴因子激活的杀伤细胞(LAK)和重组白细胞介素2_rIL_2静脉滴注,同时将胸液中的肿瘤浸润淋巴细胞(TIL)体外培养、扩增后联同_rIL_2注入胸腔治疗肺癌癌性胸腔积液30例。结果显示完全缓解(CR)16例(53％),部分缓解(PR)12例(40％),无效(NC)2例(7％)。治疗后多数患者闷喘减轻,精神好转,食欲增加,体力增强,外周血白细胞增加,PR、NC病例胸液中淋巴细胞增多,癌胚抗原(CEA)下降。除12例(40％)出现一过性发热,4例(13％)出现荨麻疹,未作处理好转。表明本疗法治疗肺癌癌性胸腔积液是有效的,能提高患者的生存时间及生活质量。 |
| 关 键 词： | 胸腔积液 淋巴因子杀伤细胞 白细胞介素2 淋巴细胞 肿瘤浸润 |
Administration of LAK cells and TIL cells combined with _rIL_2 in the treatment of lung cancer with malignant pleural effusion |
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| Zhou Guiming,Hu Qing,et al HeZe Prefecture People's Hospital of Shandong province. Administration of LAK cells and TIL cells combined with _rIL_2 in the treatment of lung cancer with malignant pleural effusion[J]. Journal of Clinical Pulmonary Medicine, 1997, 2(4): 7-8 | |
| Authors: | Zhou Guiming Hu Qing et al HeZe Prefecture People's Hospital of Shandong province |
| Affiliation: | Zhou Guiming,Hu Qing,et al HeZe Prefecture People's Hospital of Shandong province 274031 |
| Abstract: | Thirty patients with malignant pleural effusions due to lung cancer were treated by intravenous administration of LAK celles combined rIL2, and intrapleural administration of TIL cells which bed been induced and expanded out body combined with rIL2. The pleural effusions disappeared in 16 patients and significantly decreased in 12. Two patients did not respond to the treatment. No serious side effect was found in thirty patients. The results indicate that transfer of LAK cells and TIL cells combined with rIL2 in the treatment of lung cancer with malignant pleural effusions is effective and safe. |
| Keywords: | Pleural effusion Lymphokine activated killer cell Interleukin2 Lymphocytes tunor infiltrating |
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