| 壳聚糖絮凝法用于脑清口服液澄清工艺的探讨 |
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| 引用本文： | 李冬梅,路绪文,苏芳.壳聚糖絮凝法用于脑清口服液澄清工艺的探讨[J].中成药,2003,25(6):448-450. |
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| 作者姓名： | 李冬梅 路绪文 苏芳 |
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| 作者单位： | 1. 解放军第251医院,河北,张家口,075000
2. 解放军白求恩军医学院,河北,石家庄,050081 |
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| 摘 要： | 目的：探讨壳聚糖絮凝法代替乙醇沉淀法用于脑清口服液(葛根，黄芪等)制备的可行性。方法：考察两种澄清法的沉淀效果、过滤难易、对主要有效成分含量影响并对稳定性进行了比较。结果：壳聚糖絮凝法与酵沉法同样能使药液澄清，前者能更有效地保留药液中的有效成分，又能保证制剂的稳定性，缩短生产周期，降低成本。结论：壳聚糖絮凝法可代替乙醇沉淀法用于脑清口服液的澄清工艺。
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| 关 键 词： | 脑清口服液 乙醇沉淀法 壳聚糖 絮凝法 葛根素 黄芪甲苷 HPLC 澄清工艺 制备 |
| 文章编号： | 1001-1528(2003)06-0448-03 |
| 修稿时间： | 2002年4月1日 |
Study of clarifying for Naoqing Oral Liquid with chitin instead of alcohol |
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| LI Dong-mei ,LU Xu-wen ,SU Fang.Study of clarifying for Naoqing Oral Liquid with chitin instead of alcohol[J].Chinese Traditional Patent Medicine,2003,25(6):448-450. |
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| Authors: | LI Dong-mei LU Xu-wen SU Fang |
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| Institution: | LI Dong-mei 1,LU Xu-wen 1,SU Fang 2 |
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| Abstract: | Objective: To study clarifying for Naoqing Oral Liquid (Radix Puerariae, Radix Astragali, etc.) with chitin instead of ethanol. Methods: By studying precipitation effect of two clarification methods, in the meantime, studying the influence of different concentration of chitin on the clarification effect of Naoqing Oral Liquid. Results: Chitin had the more effective components than ethanol, and assured the stability of the preparation and shortened production period of the preparation. Conclusion: Chitin can clarify Naoqing Oral Liquid instead of ethanol. |
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| Keywords: | Naoqing Oral Liquid ethanol chitin clarification puerarin astragaloside I HPLC |
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