AGTR1基因多态性与糖尿病肾病易感性相关

目的：探讨Ⅰ型血管紧张素Ⅱ受体(angiotensin ⅡtypeⅠreceptor，AGTR1) A1166C 多态性与糖尿病肾病的关系。
方法：用聚合酶链反应-限制性片段长度多态性技术研究AGTR1多态性在正常对照组(157例)、2型糖尿病非肾病组（141例，糖尿病病程≥10年）、2型糖尿病肾病组（152例）中的基因频率分布。
结果：2型糖尿病肾病组AGTR1 C等位基因频率明显高于正常对照组和2型糖尿病非肾病组(P<0.05)，正常对照组与2型糖尿病非肾病组间差异无统计学意义。
结论：AGTR1 A1166C基因多态性与糖尿病肾病相关，即C等位基因携带可能增加糖尿病肾病的发生风险。

AGTR1 A1166C polymorphism is associated with risk of diabetic nephropathy

Objective： To investigate whether the angiotensinⅡtypeⅠreceptor gene (AGTR1) A1166C polymorphism is associated with a high risk of diabetic nephropathy.
Methods： The allele frequency and the genotype distribution of the AGTR1 A1166C polymorphism were studied in normal controls (157 cases)，simple diabetes (141 cases,duration of diabetes ≥10 years)，and diabetic nephropathy (152 cases) by means of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
Results： Patients with diabetic nephropathy had a higher frequency of C allele of the AGTR1 A1166C polymorphism than that of normal controls and simple diabetes (P<0.05); but there was no significant difference in frequency of C allele between the normal controls and patients with simple diabetes.
Conclusion： The diabetic patients with AGTR1 C allele may be more susceptible to diabetic nephropathy than diabetic patients with A allele.