Effect of cortisone on cells at the bone-marrow interface |
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Authors: | David J Simmons PhD Louis Kidder Mary Thomas |
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Institution: | (1) Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, USA;(2) Division of Orthopedic Surgery, University of Texas Medical Branch, Department of Surgery, 77550 Galveston, TX, USA |
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Abstract: | Summary A study of the association between the rate of proliferation of marrow fibroblast-like stromal cells (in vitro) and the rate of endosteal bone mineralization (EsMR) (in vivo) was undertaken in an osteopenic rat model. We report than 200 g male rats treated with cortisone acetate (5 mg/day for 7
days) exhibit decreases in marrow fibroblast colony-forming units (FCFU) and tetracycline-based measurements of EsMR at the
level of the femoral midshaft. In cortisone-treated rats recovering for 1–3 weeks, the FCFU census and EsMR normalized during
the first posttreatment week, remained at control levels after 2–3 weeks, and exhibited a relapse in the third week which
signified only partial recovery. These changes were unrelated to patterns of body weight gain. The data indicate that the
FCFU census can serve to index endosteal osteoblast vigor. |
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Keywords: | Glucocorticoid Stromal cell Marrow Bone formation Osteopenia |
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