早期胃癌患者淋巴结转移的危险因素分析

目的 探讨早期胃癌淋巴结转移的危险因素,研究早期胃癌淋巴结转移与临床病理因素的关系.方法 根据术中探查发现及术后病理结果确诊,将215例早期胃癌患者分为淋巴结转移组(36例)和无淋巴结转移组(179例),对2组患者的临床病理资料进行回顾性分析.结果 2组患者性别、年龄、肿瘤部位、肿瘤类型、分化程度比较差异均无统计学意义(均P＞0.05)；肿瘤浸润深度、肿瘤最大直径和幽门螺杆菌(Hp)感染2组比较差异均有统计学意义(均P＜0.05).Logistic多因素回归分析显示:肿瘤浸润深度与早期胃癌淋巴结转移的发病有关(OR=3.103,95％CI:1.495～6.609).结论 肿瘤的浸润深度是影响早期胃癌淋巴结转移的独立危险因素.

Risk Factors for Lymph Node Metastasis in Patients with Early Gastric Cancer

Objective To investigate the risk factors for lymph node metastasis in patients with early gastric cancer, and to explore the relationship between lymph node metastasis from early gastric cancer and clinical pathological factors. Methods According to intraoperative findings and postoperative pathological results, 215 patients with early gastric cancer were divided into lymph node metastasis group （n=36）and non-metastasis group （n=179）. Clinical and pathological data of patients were analyzed retrospectively. Results There were no significant differences in gender, age, tumor location, tumor type and differentiation degree between the two groups （P〉0.05）. However, the differences in tumor invasion depth, maximum tumor diameter and Helicobacter pylori infection were obvious between the two groups （P〈0.05）. Multivariable logistic regression analysis revealed that tumor invasion depth was correlated with lymph node metastasis in patients with early gastric cancer （OR= 3.103, 95%CI=1.495-6.609）. Conclusion Tumor invasion depth is an independent risk factor for lymph node metastasis in patients with early gastric cancer.