双歧杆菌三联活菌胶囊对幽门螺杆菌感染的消化性溃疡的治疗作用

目的：观察双歧杆菌三联活菌胶囊对幽门螺杆菌（Helicobacter pylori, H.pylori）感染的消化性溃疡的治疗作用。方法：H.pylori感染的消化性溃疡患者120例，随机分为2组：对照组用埃索美拉唑镁+阿莫西林+呋喃唑酮三联抗H.pylori治疗，治疗组用上述三联抗H.pylori治疗+双歧杆菌三联活菌胶囊，观察治疗前及治疗2周后胃液pH值、胃内菌群变化、不良反应、溃疡及糜烂愈合情况，治疗结束后4周复查14C-尿素呼气试验，观察H.pylori根除率。结果：2组治疗后胃液pH值均较治疗前明显升高（P<0.05），胃液pH值≥4时，治疗组胃液细菌培养阳性率低于对照组（分别为80.0%与97.4%，P<0.05）；治疗组不良反应发生率低于对照组（分别为11.7%与30%，P<0.05）；治疗2周后，治疗组与对照组溃疡治愈率分别为80.0%与73.3%（P>0.05），治疗组糜烂治愈率高于对照组（分别为68.7%与40.7%，P<0.05）；治疗组H.pylori根除率高于对照组（PP分析分别为80.4%与62.3%，P<0.05）。结论：在抗H.pylori治疗时加用双歧杆菌三联活菌胶囊能减少胃内细菌生长，降低不良反应，提高H.pylori根除率，促进糜烂愈合。

Effect of birid triple viable on peptic ulcer patients with Helicobacter pylori infection

ObjectiveTo observe the effect of birid triple viable on peptic ulcer patients with Helicobacter pylori(H.pylori) infection.MethodsA total of 120 peptic ulcer patients with H.pylori infection was randomly divided into 2 groups. The control group was treated with the triple therapy including Esomeprazole, Amoxicillin, and Furazolidone. The treatment group was treated with the same triple therapy plus birid triple viable. The pH values of the gastric juice, bacterial culture of the gastric juice, the therapy-related side effects and the healing rate of ulcer and erosive were observed before the treatment and after a 14-day-treatment respectively. The 14C-urea breath test(14C-UBT) was used to evaluate the H.pylori eradication rates 4 weeks after the treatment.Results After the treatment, pH values of the gastric juice in both groups were significantly higher than those before the treatment (P<0.05). When pH values of the gastric juice ≥4, the positive rate of bacterial culture in the treatment group was lower than that of the control group (80.0% and 97.4% respectively, P<0.05). The rate of adverse effects in the treatment group was lower than that in the control group(11.7% and 30% respectively, P<0.05).After a 2-week treatment, the healing rate of ulcer and erosion was 80% and 68.7% in the treatment group, and 73.3% and 40.7% in the control group. The healing rate of ulcer had no significant difference in the 2 groups(P>0.05),while the healing rate of erosion in the treatment group was higher than that of the control group (P<0.05).The H.pylori eradication rates evaluated by per-protocol(PP) analysis in the treatment group was significantly higher than that of the control group (80.4% and 62.4% respectively, P<0.05).ConclusionThe combined use of birid triple viable and the triple therapy of H.pylori in peptic ulcer patients with H.pylori infection can reduce the bacteria of the gastric juice and therapy-related side effects. It can increase the H.pylori eradication rate and promote the healing of erosion.