中枢神经系统感染患儿血脑屏障与脑脊液白蛋白指数的变化

目的探讨中枢神经系统感染患儿血脑屏障（blood-brain barrier,BBB）与脑脊液（cerebrospinal-fluid,CSF）白蛋白指数的变化。方法采用溴甲酚绿法和免疫比浊法检测18例化脓性脑膜炎患儿急性期、恢复期及22例病毒性脑炎患儿急性期血清和CSF中白蛋白水平,并计算出CSF白蛋白指数。与正常对照组比较。结果化脓性脑膜炎、病毒性脑炎患儿急性期CSF白蛋白、CSF白蛋白指数显著高于正常对照组（P〈0.001）,且化脑组显著高于病脑组（P〈0.001）。化脑组恢复期患儿CSF白蛋白、CSF白蛋白指数与对照组无明显差异（P〉0.05）。结论监测CSF白蛋白和CSF白蛋白指数的水平可作为化脓性脑膜炎和病毒性脑炎早期诊断、鉴别诊断,以及判断BBB损伤程度的参考指标。

Changes of cerebrospinal-fluid albumin index and blood-brain barrier in children with central nervous system infection

Objective:To observe the changes of cerebrospinal-fluid(CSF) albumin index and blood-brain barrier(BBB) in children with central nervous system infection.Methods: The levels of albumin in serum and CSF were determined by using immunoturbidimeter method in 18 children with purulent meningitis(PM) in acute phase and recovery phase,22 children with viral encephalitis(VE) in acute phase,and 20 normal children.Results:In acute phase,the levels of CSF albumin and CSF albumin index in children with PM and VE were obviously higher than those of contral group(P<0.001),and the levels of CSF albumin and CSF albumin index in children with PM were obviously higher than those of VE(P<0.001).In recovery phase,the difference of CSF albumin and CSF albumin index between PM and contral group was of no statistical significance(P>0.05).Conclusions:The levels of CSF albumin and CSF albumin index potentially have an important value in early diagnosis,identity diagnosis,judgement of BBB impairment in PM and VE.