P物质在慢性鼻窦炎嗅黏膜中的表达及其意义

目的 :探讨慢性鼻窦炎患者嗅觉功能障碍的发病机制。方法 :采用免疫组织化学方法对慢性鼻窦炎5 5例和对照组 11例的嗅黏膜进行P物质 (SP)检测 ;用苏木精 伊红染色方法观察嗜酸性粒细胞的浸润程度。结果 :鼻窦炎组嗅黏膜嗜酸性粒细胞阳性者 4 9例 (89.1% ) ,对照组 1例 (18.2 % ) ,差异有统计学意义 (P <0 .0 5 ) ;SP在慢性鼻窦炎嗅黏膜的嗅细胞、支持细胞、基底细胞、腺体、血管上皮及部分淋巴细胞、嗜酸性粒细胞中均有阳性表达 ,鼻窦炎组阳性表达 4 5例 (81.8% ) ,对照组 1例 (9.1% ) ,差异有统计学意义 (P <0 .0 1)。结论 :慢性鼻窦炎嗅黏膜的变态反应性改变是引起嗅觉功能障碍的主要因素之一 ,与SP在嗅黏膜中表达增高有关。

Research of the P substance on the olfactory mucous in sinusitis

Objective:To discuss the pathogenesis of dysosphresia in the chronic sinusitis patients.Method:Fifty-five cases with chronic sinusitis as experimental group, and 11 cases as control,mere analyzed with acidophilus monitor, and then the P substances in their olfactory mucous were detected.Result:The positive ratio is 50.9% in the chronic sinusitis patients with dysosphresia, acidophilus monitor in factory mucous was 89.1%. Furthermore, it showed the SP locating in the olfactory cells, support cells, basal cell, glands, epithelium cells of blood vessels, a few of lymphocytes and acidophilus by using the histochemical, immunohistochemical technique (S-P method).Conclusion:The allergy change of olfactory mucous is one of the main factors that draw olfactory function disorder.