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| 血红蛋白加氧酶1与脂肪肝缺血/再灌注损伤 | |
| 引用本文： | 秦红波,曹浩强. 血红蛋白加氧酶1与脂肪肝缺血/再灌注损伤[J]. 医学综述, 2008, 14(13): 1924-1926 |
| 作者姓名： | 秦红波 曹浩强 |
| 作者单位： | 嘉兴市第二医院肝胆外科,浙江,嘉兴,314000 |
| 摘 要： | 脂肪肝肝移植术后原发性肝无功能发生率较高,目前认为主要是因为移植术后脂肪肝缺血/再灌注损伤程度较重造成的。血红蛋白加氧酶1(HO-1)是血红蛋白代谢为胆绿素、一氧化碳和二价铁离子过程中的限速酶。研究发现,HO-1过表达能降低肝移植中脂肪肝供肝的缺血/再灌注损伤,提高移植物的存活率。本文综述HO-1降低脂肪肝缺血/再灌注损伤的可能机制。 |
| 关 键 词： | 血红蛋白加氧酶1 脂肪肝 缺血/再灌注损伤 |
Heme Oxygenase-1 and Fatty Liver Ischemia Reperfusion Injury |
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| QIN Hong-bo,CAO Hao-qiang. Heme Oxygenase-1 and Fatty Liver Ischemia Reperfusion Injury[J]. Medical Recapitulate, 2008, 14(13): 1924-1926 | |
| Authors: | QIN Hong-bo CAO Hao-qiang |
| Affiliation: | QIN Hong-bo,CAO Hao-qiang.(Department of Hepatobiliary Surgery,Second Hospital of Jiaxing,Jiaxing 314000,China) |
| Abstract: | Ischemia reperfusion injury is a major cause for primary liver dysfunctional with high rate after liver transplantation for fatty liver.Heme oxygenase-1 (HO-1) is the rate-limiting enzyme produced in heme into biliverdin,carbon monoxide and free iron.The overexpression of HO-1 can decrease the ischemia reperfusion injury and increase the graft survival in fatty liver transplantation.This article reviewed the possible mechanism of HO-1 decreasing the ischemia reperfusion injury in fatty liver. |
| Keywords: | Heme oxygenase-1 Fatty liver Ischemia reperfusion injury |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |