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Plasma cell dyscrasia with kappa light-chain crystals in proximal tubular cells: a histological, immunofluorescent, and ultrastructural study |
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| Authors: | Cai Guoping Sidhu Gurdip S Wieczorek Rosemary Gu Xin Herrera Guillermo A Cubukcu-Dimopulo Olcay Kahn Thomas |
| Affiliation: | a Department of Pathology, New York University Medical Center, New York, New York, USAb Department of Pathology, New York Harbor Healthcare System, New York, New York, USAc Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USAd Department of Pathology, Bronx Veterans Administration Medical Center, New York, New York, USAe Department of Medicine, Bronx Veterans Administration Medical Center, New York, New York, USA |
| Abstract: | This is a case report of a 56-year-old man with plasma cell dyscrasia who presented with proximal tubulopathy manifested as kappa light-chain crystal deposition in the proximal convoluted tubular cells. This was associated with mild cellular damage. The crystals were seen as negative images with the hematoxylin-eosin and periodic acid-Schiff (PAS) stains. They were identified as kappa light-chains by immunofluorescent imaging and confirmed by immunoelectron microscopy. Ultrastructurally, the crystals appear to be located within lysosomes. No deposits of light-chains were seen elsewhere in the kidney biopsy. |
| Keywords: | crystal immunoelectron microscopy kappa light-chain plasma cell dyscrasia proximal tubulopathy ultrastructure |
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