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| 糖尿病视网膜病变病人血清APN和hs-CRP变化及意义 | |
| 引用本文： | 于春庆,林萍,刘芝军. 糖尿病视网膜病变病人血清APN和hs-CRP变化及意义[J]. 青岛大学医学院学报, 2011, 47(6): 509-511 |
| 作者姓名： | 于春庆 林萍 刘芝军 |
| 作者单位： | 1. 莱州市疾病预防控制中心,山东莱州,261400 2. 青岛大学医学院附属医院质控处 3. 青岛大学医学院附属医院低温医学科 |
| 摘 要： | 目的探讨糖尿病视网膜病变(DR)与血清脂联素(APN)和超敏C-反应蛋白(hs-CRP)浓度变化的关系。方法采用酶联免疫吸附测定法和散射速率比浊法检测62例DR病人血清APN和hs-CRP浓度的变化,并与82例非DR(NDR)糖尿病病人及68例正常对照者进行比较,对32例增殖型DR(PDR)病人与30例非增殖型DR(NPDR)病人血清APN和hs-CRP浓度进行比较。结果 DR病人血清APN浓度明显降低,hs-CRP浓度明显升高,与对照组和NDR组比较差异有显著性(F=110.581、84.789,q=12.942～19.021,P<0.001),PDR病人血清APN浓度明显低于NPDR病人,hs-CRP浓度明显高于NPDR病人(t′=3.725、4.811,P<0.001)。DR病人血清APN与hs-CRP浓度呈负相关(r=-0.554,P<0.01)。结论血清APN和hs-CRP浓度变化参与DR的发生与发展,且与病情严重程度有关。 |
| 关 键 词： | 糖尿病视网膜病变 糖尿病血管病变 脂联素 C反应蛋白质 |
CHANGES AND SIGNIFICANCE OF SERUM ADIPONECTIN AND HIGH SENSITIVITY C-REACTIVE PROTEIN IN PATEINTS WITH DIABETIC RETINOPATHY |
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| YU Qingchun,LIN Ping,LIU Zhijun. CHANGES AND SIGNIFICANCE OF SERUM ADIPONECTIN AND HIGH SENSITIVITY C-REACTIVE PROTEIN IN PATEINTS WITH DIABETIC RETINOPATHY[J]. Acta Academiae Medicinae Qingdao Universitatis, 2011, 47(6): 509-511 | |
| Authors: | YU Qingchun LIN Ping LIU Zhijun |
| Affiliation: | YU Qingchun,LIN Ping,LIU Zhijun(Disease Prevention and Control Center of Laizhou,Laizhou 261400,China) |
| Abstract: | Objective To investigate the relationship between diabetic retinopathy(DR) and changes of serum adiponectin(APN) and high sensitivity C-reactive protein(hs-CRP).Methods Using ELISA and nephelometry,serum levels of APN and hs-CRP in 62 DR patients were determined and compared with that in 82 diabetes patients without DR(NDR),and 68 normal controls.The serum APN and hs-CRP in 32 proliferative diabetic retinopathy(PDR) patients were compared with that in 30 non-PDR(NPDR) patients.Results The serum APN in DR pa... |
| Keywords: | diabetic retinopathy diabetic angiopathies adiponectin C-reactive protein |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |