血管内皮生长因子受体（KDR）在胃癌浸润和转移中的作用探讨

目的探讨血管内皮生长因子受体（KDR）在胃癌中的表达及其临床意义。方法收集60例手术切除的胃癌标本，同时取距离肿瘤组织5cm以上的正常组织，采用免疫组织化学sP法检测癌组织及癌旁组织中KDR的表达。结果60例患者中胃癌组织KDR的阳性率为55％，癌旁组织中为18．3％，KDR在胃癌组织内的阳性表达率明显高于癌旁组织，差异有统计学意义（P〈0．01）；KDR的阳性表达率随着胃癌组织的TNM分期I～Ⅳ期进展不断增高，具有统计学意义（P〈0．05）。结论KDR在胃癌组织中存在高表达，且其与胃癌的TNM分期密切相关，通过检测KDR可能会对我们评估胃癌患者的预后情况提供一定的帮助。

The Role of Vascular Endothelial Growth Factor Receptor (KDR) in Invasion and Metastasis of Gastric Cancer

Objective To study the expression of vascular endothelial growth factor receptor KDR in gastric cancer and its clinical value. Methods Collected 60 specimens from gastric cancer patients. The expression of KDR in gastric cancer tissues and their adjacent normal tissues were detected with SP immunohistochemistry. Results The positive rate of KDR expression in gastric cancer tissue was higher than that in normal tissue （ 55.0% vs 18.3% ）. There was significant difference in the expression of KDR between the gastric cancer tissue and their adjacent normal tissue （P 〈 0.01 ）. Besides, the expression rate of KDR in gastric cancer tissue was correlated with gastric cancer TNM stages （P 〈 0.05 ）. Conclusion KDR is highly expressed in gastric cancer tissues, and it is closely related to the TNM staging of gastric cancer. To detect the expression of KDR in gastric cancer tissues may be helpful to evaluate the prognosis of patients with gastric cancer.