| 麦迪霉素在水溶液中稳定性的研究 |
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| 引用本文： | 王玉波,李丽燕. 麦迪霉素在水溶液中稳定性的研究[J]. 沈阳药科大学学报, 1984, 0(2) |
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| 作者姓名： | 王玉波 李丽燕 |
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| 作者单位： | 沈阳药学院微生物制药，沈阳药学院抗生素教研室 46期学生 |
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| 摘 要： | 本实验用分光光度法对麦迪霉素的稳定性进行研究。结果表明在55℃、70℃,于pH2～9范围内稳定,在50℃、55℃,65℃,pH=1.0,pH=12.0不稳定。其水解反应服从一级反应动力学公式,测得:pH=12.0:50℃,K=4.00×10~(-3)min~(-1),55℃,K=7.68×10~(-3)min~(-1),65℃,K=4.12×10~(-2)min~(-1);pH=1.0:50℃,K=1.76×10~(-3)min~(-1),55℃,K=6.41×10~(-3)min~(-1),65℃,K=2.14×10~(-2)min(-1)。并证明温度对反应速度的影响遵守阿累尼乌斯公式。求出pH=12.0,E_a=3.27×10~4cal/mol,A=3.98×10~(19);pH=1.0,E_a=3.43×10~4cal/mol,A=3.98×10~(20),并建立具体的阿累尼乌斯公式: pH=12.0:1gK=-7.1×10~3·_T~1+19.6 pH=1.0:1gK=-7.5×10~3·(1/T)+20.6
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| 关 键 词： | 麦迪霉素 稳定性 一级反应 动力学方程 速度常数 |
STUDIES ON STABILITY OF MEDEMYCIN IN AN AQUEOUS SOLUTION |
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| Wang Yubou Li Liyan. STUDIES ON STABILITY OF MEDEMYCIN IN AN AQUEOUS SOLUTION[J]. Journal of Shenyang Pharmaceutical University, 1984, 0(2) |
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| Authors: | Wang Yubou Li Liyan |
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| Affiliation: | Wang Yubou Li Liyan Department of Antibiotics |
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| Abstract: | In the experiment, we studied the stability of medemycin by means of spectrophotometry.The results showed that medemycin is stable at 55℃, 70℃ over a pH range of 2—9, but not stable at 50℃,55℃, 65℃, or when pH=1.0,pH=12. The hydrolytic reaction of medemycin complies with a first—order reaction of kinetic equation.According to the kinetic equation, we determined: pH=12 50℃, K=4.00×10~(-3)min~(-1), 55℃, K=7.68×10~(-3)min~(-1) 65℃, K=4.12×10~(-2)min~(-1) pH=1.0 50℃, K=1.76×10~(-3)min~(-1), 55℃, K=6.41×10~(-3)min~(-1), 65℃, K=2.14×10~(-2)min~(-1), It was also proved that the action of temperature on the rate constant complies Arrhenius equation.Calculating E. and A for the Arrhenius equation: pH=12, E_a=3.27×10~4cal/mol A=3.98×10~(19) pH=1.0 E_s=3.43×10~4cal/mol A=3.98×10~(20) Then the Arrhenius equation was definitely established: pH=12 lg K=-7.1×10~31/T+19.6 pH=1.0 lg K=-7.5×10~31/T+20.6 |
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| Keywords: | Medemycin First-order reaction Stability kinetic equation Rate constant |
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