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Metabolomics discloses donor liver biomarkers associated with early allograft dysfunction

Authors:	Miriam Cortes Eugenia Pareja Juan C García-Cañaveras M Teresa Donato Sandra Montero Jose Mir José V Castell Agustín Lahoz

Institution:	¹ Unidad de Hepatología Experimental, Instituto de Investigación Sanitaria – Fundación Hospital La Fe, Valencia, Spain;² Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Valencia, CIBERehd, Centro de Investigaciones Biomédicas en Red de Enfermedades Hepáticas y Digestivas, FIS, Spain;³ Unidad Analítica, Instituto de Investigación Sanitaria – Fundación Hospital La Fe, Valencia, Spain

Abstract:

Keywords:	EAD early allograft dysfunction IGF immediate graft function OLT orthotopic liver transplantation PNF primary non function ICU intensive care unit INR international normalized ratio ALT alanine aminotransferase AST aspartate aminotransferase MELD Model For End-Stage Liver Disease UPLC Ultra-performance liquid chromatography QToF quadrupole time of flight RP reverse phase HILIC hydrophilic interaction chromatography MVDA multivariate data analysis IS internal standard PCA principal component analysis PLSDA projection to latent structure discriminant analysis CV cross-validation BA bile acid GSK glycogen synthase kinase JNK c-Jun N-terminal kinase REIMS rapid evaporative ionization mass spectrometry
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