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Warm vs. cold perfusion techniques to rescue rodent liver grafts
Authors:Andrea Schlegel  Philipp KronRolf Graf  Philipp Dutkowski  Pierre-Alain Clavien
Affiliation:Department of Surgery, University Hospital Zurich, Swiss HPB and Transplant Center, Zurich, Switzerland
Abstract:
Keywords:DCD, donation after cardiac death   HOPE, hypothermic oxygenated perfusion   UW solution, University of Wisconsin solution   HMGB-1, high mobility group box-1 protein   8-OHdG, 8-hydroxy-2-deoxy guanosine   H&  E, haematoxylin and eosin   ROS, reactive oxygen species   DAMPs, damage associated molecular pattern signalling   CD68, macrosialin   ELISA, enzyme-linked immunosorbent assay   SECs, sinusoidal endothelial cells   WI, warm ischemia   IPRL, isolated perfused rat liver   TLR-4, Toll-like receptor 4   MPO, myeloperoxidase   IL-6, interleukin 6   IL-10, interleukin 10   IL-1β, interleukin 1β   TNF-α, tumor necrosis factor alpha   ICAM-1, intercellular adhesion molecule-1   NSE, neuron specific enolase   CXCL-5 (ENA-78), epithelial neutrophil-activating protein 78
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