ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis |
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| Authors: | Raquel Fucho,Laura Martí nez,Anna Baulies,Sandra Torres,Nuria Tarrats,Anna Fernandez,Vicente Ribas,Alma M. Astudillo,Jesú s Balsinde,Pablo Garcia-Rové s,Montserrat Elena,Ina Bergheim,Sophie Lotersztajn,Christian Trautwein,Hanna Appelqvist,Adrienne W. Paton,James C. Paton,Mark J. Czaja,Neil Kaplowitz,Jose C. Fernandez-Checa,Carmen Garcí a-Ruiz |
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| Affiliation: | 1 Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona, Spain;2 Liver Unit, IDIBAPS Hospital Clinic de Barcelona and CIBEREHD, Barcelona, Spain;3 Institute of Molecular Biology and Genetics CSIC, Medical School, University of Valladolid and CIBERDEM, Valladolid, Spain;4 Diabetes and Obesity Laboratory, IDIBAPS-Hospital Clinic de Barcelona, Barcelona, Spain;5 Biochemical Service, Hospital Clinic de Barcelona, Barcelona, Spain;6 Department of Nutritional Sciences, Friedrich-Schiller-University, Jena, Germany;7 Université Paris-Est, UMR-S955, UPEC, Créteil, France;8 Department of Internal Medicine III, University Hospital, RWTH Aachen, Aachen, Germany;9 Experimental Pathology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden;10 Research Centre for Infectious Diseases, School of Molecular and Biomedical Science, University of Adelaide, Australia;11 Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, United States;12 Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States |
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| Abstract: | ![]()
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| Keywords: | ASMase, acid sphingomyelinase A-LDLR-DKO, ASMase/LDL receptor double knockout mice CHQ, chloroquine ER, endoplasmic reticulum FFA, free fatty acids GTT, glucose tolerance test ITT, insulin tolerance test IRβ, insulin receptor β subunit HCD, high cholesterol diet HFD, high fat diet LMP, lysosomal membrane permeabilization MDC, monodansylcadaverine MCD, methionine choline deficient diet MSDH, O-methyl-serine dodecylamide hydrochloride PA, palmitic acid PMH, primary mouse hepatocytes RAPA, rapamycin RD, regular diet SubAB, AB5 subtilase cytotoxin SMase, sphingomyelinase SM, sphingomyelin SMS, sphingomyelin synthase SPT, serine palmitoyl transferase TG, triglycerides |
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