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Hepatoblastoma cells express truncated neurokinin-1 receptor and can be growth inhibited by aprepitant in vitro and in vivo
Authors:Michael Berger,Olaf Neth,Matthias Ilmer,Agnè  s Garnier,Manuel Vicente Salinas-Martí  n,Juan Carlos de Agustí  n Asencio,Dietrich von Schweinitz,Roland Kappler,Miguel Muñ  oz
Affiliation:1 Division of Pediatric Infectious Disease and Immunopathology, Virgen del Rocío Children’s Hospital, Institute of Biomedicine, Seville, Spain;2 Department of Pediatric Surgery, Research Laboratories, Dr. von Hauner Children’s Hospital, Ludwig-Maximilians-University Munich, Germany;3 Department of Translational Molecular Pathology, MD Anderson Cancer Center, University of Texas Health Science Center at Houston, TX, USA;4 Department of Pathology, Juan Ramón Jiménez Hospital, Huelva, Spain;5 Department of Pediatric Surgery, Virgen del Rocío Children’s Hospital, Seville, Spain;6 Research Laboratory on Neuropeptides, Virgen del Rocío Children’s Hospital, Seville, Spain
Abstract:
Keywords:Neurokinin-1 receptor (NK1R)   Aprepitant   Substance P (SP)   Anti-tumor target   Xenograft   Apoptosis   Hepatoblastoma (HB)
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