| 人视网膜前膜中粘附分子的免疫组织化学观察 |
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| 引用本文： | 张蓉,惠延年,马吉献. 人视网膜前膜中粘附分子的免疫组织化学观察[J]. 中华眼底病杂志, 2000, 16(2): 106-108 |
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| 作者姓名： | 张蓉 惠延年 马吉献 |
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| 作者单位： | 1. 乌鲁木齐市武警新疆总队医院眼科
2. 710032,西安,第四军医大学西京医院眼科 |
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| 基金项目： | 国家自然科学基金!资助项目 (39470 742 ) |
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| 摘 要： | 目的 观察增生性玻璃体视网膜病变(Proliferative vitreoreti nopathy,PVR)的视网膜前膜(epiretinal membranes,ERM)中粘附分子(ICAM-1,Mac-1) 的表达。方法用免疫组织化学方法对20例复杂视网膜脱离行玻 璃体切割术时剥离的视网膜前膜进行观察。结果ICAM-1和Mac-1分别在18和15例视网膜前膜中表达,两种粘附分子同在12例视网膜前膜中表达。结论ERM中有ICAM-1和Mac-1的表达,提示粘附分子在PVR的发 生发展中有一定作用。（中华眼底病杂志,2000,16：71-138）
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| 关 键 词： | 视网膜病变 视网膜前膜 细胞粘附分子 |
| 收稿时间： | 1999-06-07 |
| 修稿时间： | 1999-06-07 |
An immunohistochemical study of adhesion molecules in human epiretinal membranes |
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| ZHANG Rong,HUI Yannian,MA Jixian. An immunohistochemical study of adhesion molecules in human epiretinal membranes[J]. Chinese Journal of Ocular Fundus Diseases, 2000, 16(2): 106-108 |
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| Authors: | ZHANG Rong HUI Yannian MA Jixian |
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| Affiliation: | Department of Ophthalmology,Xijing Hospital,Fourth Military Medical University,Xian 710032,China |
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| Abstract: | Purpose To investigate the expression of intercellular adhesion molecules ICAM 1 and Mac 1,in epiretinal membanes (ERM) of eyes with proliferative vitreoretinopathy (PVR). Methods Twenty epiretinal membranes were obtained from eyes undergone vitrectomy for retinal detachment complicated with PVR and observed by immunohistochemical examination. Results Expressions of ICMA 1 and Mac 1 were observed in 18 and 15 membranes respectively.Expression of both adhesion molecules in 12 membranes. Conclusion The findings indicate that adhesion molecules might be involved in the development of PVR. |
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| Keywords: | Retinal diseases/etiology Hyperplasia/etiology Intercellular adhesion molecules Immunohistochemistry Gene expression |
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