多蜂房蛋白BMI-1在子宫内膜癌中的表达及意义

目的研究BMI-1在子宫内膜癌中的发生、发展、浸润及转移中的作用及其对临床诊断、治疗以及预后评估的意义。方法运用免疫组化方法研究正常子宫内膜、增生症组子宫内膜及子宫内膜癌组织中BMI-1的表达。结果 BMI-1在子宫内膜癌组中的表达显著高于正常子宫内膜组织和增生症子宫内膜组织(分别为106.31±11.696、199.47±9.151、143.60±9.361,P<0.05),子宫内膜癌组织中的BMI-1的表达与手术-病理分期、肌层浸润深度及是否出现淋巴结转移有关,而对于组织学分级、病理类型及雌、孕激素受体方面则无统计学意义。结论 BMI-1与子宫内膜癌的发生、发展、浸润及转移密切相关。

Expression and significance of BMI-1 in endometrial carcinoma

Objective TO research the role of BMI-1in occurrence development invasion and transinformation of endometrial carcinoma,and its guiding significance in clinical diagnosis,treatment and prognosis.Methods Expression of BMI-1 were examined by immunohistochemical technique in normal endometrial tissues、endometrial hyperplasia tissues and endometrial carcinoma tissues.Results The expression level of BMI-1 system in endometrial carcinoma tissues was significantly higher than those in normal endometrium tissues and endometrial hyperplasia tissues（they are 106.31±11.696,199.47±9.151,143.60±9.361,P〈0.05）,the expression of BMI-1 system in endometrial carcinoma tissues was positively correlated with surgical-pathologicalgrades,depth of myometrial invasion,lymphatic metastasis or not;but not to histological grades、pathologic tissue differentiation character of endometrial carcinoma and estrogen or progeserone receptor.Conclusion BMI-1 is closely related to occurrence,development,invasion and transformation of endometrial carcinoma.